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Brain-derived EPO has been shown to act locally via paracrine or autocrine signaling as a neuroprotective factor, additionally stimulating neural progenitor cells, neurons, glial cells, and endothelial cells in an analogous manner to its actions on erythrocytic progenitors outside of the nervous system [29]

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Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells