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Moreover, the phosphorylated forms of AKT (p-AKT) and mTOR (p-mTOR), reflecting the activation status of this pathway, were markedly elevated in patients’ PBMCs (Fig

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Briefly, mostly ring-stage parasites were incubated at 0.2% initial parasitemia and 1% hematocrit with a range of CB-27 concentrations at 37°C for 72 h in 96-well plates as previously described ( 50 was calculated using GraphPad Prism 6 software