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Indeed, mutations in the respective genes cause a wide range of developmental malformations of the brain, bone, and heart with moderate to lethal consequences (72)

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A large-scale database study in China estimated that between 2019 and 2030, thyroid cancer would be identified in 1 million 20- to 64-year-old individuals if screening were not conducted, compared to 11.4 million cases if screening were to be performed [14]

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