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Nowadays, due to the complexity of this psychiatric disorder, there is neither molecular biomarker nor biological sign used for the diagnosis of BD in the clinical routine, so this entity remains a descriptive syndrome whose diagnosis is eminently clinical, based on the already mentioned clinical manuals such as the DSM-V and the ICD [17]

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Accurate Biology), 2.6 μL H 2 O, 2 μL cDNA template, and 0.2 μL each of forward and reverse primers (10 μM), and the reaction mixtures were run on a LightCycler 480 system (Roche, Germany)

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