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To avoid this pitfall, we here use PAR2-mutant mice (PAR2-G37I and PAR2-R38E) that retain activation-independent signaling receptor platforms involving PAR2, while abolishing cleavage sensitivity to specific proteases (21, 22, 30, 31)

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Treatment targets Clinical targets of therapy (statement #14: grade of recommendation D) For early diagnosed patients , treatment can realistically aim to prevent all the complications of CBS deficiency , whilst maintaining normal growth and nutrition and allowing the patient normal opportunities for employment and family life