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However, compounds found in coffee, particularly polyphenols, can stimulate the Nrf2 pathway, which governs the expression of genes involved in antioxidant defense and detoxification [84]

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Microglia, the primary innate immune cells of the central nervous system, plays a central role in neuroinflammation through multiple mechanisms, including the release of pro/anti-inflammatory factors, phagocytosis, and antigen presentation (Peruzzotti-Jametti et al., 2024)