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Conservative cycling with breaks between protocols reduces exposure and potential accumulation risks even though specific dangers remain unidentified

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19.2.3.3 ABCG2 The third ABC drug efflux pump of clinical relevance in drug resistance of tumor cells is ABCG2 (formerly BCRP), which was first cloned from a drug-resistant breast cancer cell line that expressed neither P-glycoprotein nor MRP1 (Doyle et al, 1998)