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The dissociation constant is usually written as a quotient of the equilibrium concentrations (in mol/L), denoted by (HA), (A - ) and (H 3 O + ) K a = (A - )*(H 3 O + ) / (HA)*(H 2 O) In all, but the most concentrated, aqueous solutions of an acid the concentration of water can be taken as constant and can be ignored

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Clin Cancer Res (2011) 17:6239–49