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Comprendere perché la forma conta richiede di distinguere tra biodisponibilità locale (quanta molecola raggiunge il tessuto adiacente al sito di applicazione) e biodisponibilità sistemica (quanta molecola entra nel circolo sanguigno)

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Moreover, the chemical nature of the C-terminal residue side chain determines ligand contact with RAMP and can influence activity at AMYRs and CTR 18,19