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We showed that combined challenge of hiMC with pharmacological doses of the non-essential amino acids glutamine and arginine reduced leukotriene C 4 (LTC 4 ) secretion by about 45%, but not β-hex release

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The crystal structure of the human enzyme cocrystallized with glutamate showed that the α-carboxylate of the γ-glutamyl moiety of the substrate is stabilized within the active site of the enzyme by forming hydrogen bonds with Arg-107, Ser 451, and Ser-452S (West et al., 2013b)