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Potential drug interactions Sermorelin has no known major drug interactions, but may have the following interactions with certain drugs: Glucocorticoids (prednisone) May blunt growth hormone (GH) release Oral estrogens May increase IGF-1 resistance Insulin or sulfonylureas May alter glycemic control Somatostatin analogs May antagonize Sermorelin’s effects Dopamine antagonists May disrupt human growth hormone (HGH) regulation GABAergic meds May reduce pulsatility of HGH release Beta blockers (Metoprolol or Propranolol) Other secretagogues/peptides May result in unsafe levels of HGH Other important safety information Sermorelin is only for users who are at least 30 years old