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Projections from VH to medial prefrontal cortex mediate anxiety, context aversion and behavior inhibition in mice ( Impaired adult neurogenesis following chronic stress might dysregulate such neural pathways, contributing to anxiety and depression ( Rodent studies suggest that diminished DG inhibition by adult-born neurons might result in hyperactivation of hypothalamus–pituitary–adrenal (HPA) axis resulting in increased levels of glucocorticoid release in a vicious cycle detrimental to AHN ( Impaired pattern separation and cognitive flexibility have been reported in depressed humans ( Although this paper discusses the etiology of affective disorders, such as de-depression and anxiety, as related to impairment of memory-associated DG functions like pattern separation and cognitive flexibility, anxiety behavior and other affective disorders might be related to other factors, including malfunction of reward processing and innate components ( An Evolutive Reason to Explain Why Aerobic Exercise and Enriched Environment Are Beneficial for Brain Cognition and Psychic Well-Being As we mentioned before, aerobic exercise is a powerful inducer of AHN in rodents ( Homo erectus , evolved to walk in a bipedal posture and were hunter-gatherers for million years ( During the endurance hunting, early hominids practiced intense aerobic activity walking or running for up to 15 km per day to capture animals

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