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In contrast, TCM, characterized by its multi-component, multi-target actions and low toxicity, along with its personalized strategies based on syndrome differentiation and a favorable safety profile, can simultaneously regulate gut microbiota composition, promote the production of beneficial metabolites, inhibit inflammatory pathways, and modulate key ferroptosis molecules

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The metabolic activation of APAP is principally catalyzed by cytochrome P450 enzymes (17) and the reactive metabolite of greatest relevance for hepatotoxicity is generally believed to be N-acetyl-p-benzoquinone imine (NAPQI) (66)

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