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Apolipoprotein Receptor 2 and X11α/β Mediate Apolipoprotein E-Induced Endocytosis of Amyloid-β Precursor Protein and β-Secretase, Leading to Amyloid-β Production | Journal of Neuroscience

[0001937] Susceptible to: An individual who is "susceptible to" a disease, disorder, and/or condition has not been diagnosed with and/or may not exhibit symptoms of the disease, disorder, and/or condition but harbors a propensity to develop a disease or its symptoms

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This reprogramming creates a unique metabolic dependency that renders cancer cells vulnerable to selective metabolic enzyme inhibitors ( Lactate dehydrogenase A (LDHA) is a critical enzyme that converts pyruvate to lactate, regenerating NAD + to sustain anaerobic glycolysis