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Notch The Notch is an evolutionarily conserved cellular signaling pathway that mediates intercellular communication and is involved in the regulation of most tissue development and homeostasis

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This study aimed to uncover the potential therapeutic mechanism of natural products (NP or NPs) against SCA3 using an integrative computational strategy combining network pharmacology, molecular docking, molecular dynamics (MD) simulation, principal component analysis (PCA), free energy landscape (FEL), dynamic cross-correlation matrix (DCCM), and Molecular Mechanics/Poisson–Boltzmann Surface Area (MM/PBSA) calculations