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Mechanistic studies demonstrated that SOCS2 directly binds to SLC7A11 (a critical subunit of System Xc - ) via its E3 ubiquitin ligase activity, thereby promoting the K48-linked ubiquitination and degradation of SLC7A11

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Chronic oxidative stress, mitochondrial dysfunction, Nrf2 activation and inflammation in the hippocampus accompany heightened systemic inflammation and oxidative stress in an animal model of Gulf War illness