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Capsid mutated adeno-associated virus delivered to the anterior chamber results in efficient transduction of trabecular meshwork in mouse and rat

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Intriguingly, the inhibitory effects are mitigated by the treatment with UNC1999 (an inhibitor of H3K27me3) and 5-aza-2’-deoxycytidine (a DNA methyltransferase inhibitor) (unpublished data) (58, 60), suggesting methionine or SAM reduces the production of inflammatory factor in association with the histone and DNA methylation modification of specific genes