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Since nausea and fatigue tend to peak 12 to 48 hours after injection, choosing a Friday injection means the worst of any side effects falls on the weekend for most people

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In the second, MDMA becomes HMMA (4-hydroxy-3-methoxymethamphe-tamine), its major metabolite, by means of O-demethylation, followed by catechol-O-methyltrans-ferase (COMT), which occurs by means of cytochrome P 450 system CYP2D6 isoenzyme© (12)