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Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Experimental Lower-Extremity Ischemia–Reperfusion Injury

However, despite encouraging in vitro and preclinical data, clinical translation remains limited by challenges in formulation, solubility, manufacturing scalability and regulatory status

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For example, administration of naphthalene to male Swiss mice resulted in severe bronchiolar epithelial necrosis at doses at which hepatic and renal necrosis were not observed (Warren et al, 1982)