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Nuclear factor-kappa B (NF-κB) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, as well as genes involved in cell proliferation, adhesion, survival, and differentiation

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Exposure of corneal endothelial cell lines to sulforaphane decreased ROS production, enhanced cell viability and significantly upregulated ARE-dependent antioxidants reducing oxidative stress-triggered apoptosis in FECD [170]

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