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In mammals, mtDNA inheritance is almost exclusively maternal, while paternal mtDNA is actively degraded in many species immediately after fertilization ( Despite the advancements in understanding the mitochondrial structure and its role in cellular respiration via OXPHOS, the question of how the oxidation of substrates was coupled to the synthesis of ATP from ADP and inorganic phosphate was finally solved quite some time later by Peter D

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10.1016/j.freeradbiomed.2009.07.035 71 KennedyM