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Positive modulation of SOD3, either in SOD3-transgenic mice or via administration of the pharmacological SOD-mimetic MnTE-2-PyP to WT or SD3-KO mice, attenuated features of emphysema and reduced oxidative fragmentation of the ECM in mouse lungs [191]

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To do this, we first confirmed that both cytosolic- and mitochondrial-targeted Apollo-NADP + sensors are expressed in appropriate compartments of RAW264.7 Mφs