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Abstract Cluster of differentiation 38 (CD38) is a widely expressed transmembrane glycoprotein in various human tissues and cells with vital biological roles in the heart and brain, possessing both NADase and cyclase activities

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The activation of G s protein will then have a double effect: (1) It induces the release of GH stored in secretory granules by allowing the entry of Ca ++ into the cell, and (2) the α s subunit activates the adenylyl cyclase (AC), which leads to increased cellular levels of cAMP [26, 30, 31]