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2,3 This is of importance because the gut microbiota fulfills many critical roles in essential host functions such as protection against pathogens, immune-system modulation, fermentation of non-digestible dietary fibres, anaerobic metabolism of peptides and proteins, interaction with the host’s circadian clock and biotransformation of xenobiotics

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De novo phosphatidylethanolamine synthesis via the cytidine diphosphate-ethanolamine pathway is critical for maintaining CXCR5 surface expression by preventing its internalization and degradation