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The lentiviral-gene delivery of CXCL12 into TNFR2 −/− mice could rescue this effect, suggesting a TNF-α-mediated mechanism of remyelination via astrocytic CXCL12 (Patel et al., 2012)

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These upshots imply that Vitamin B12 could be the wonder molecule to shrink the virulence by hindering the furin mediated entry of spike to host cell