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This enrolled 390 people with type 2 diabetes, all on insulin, and randomised them to metformin 850 mg three times daily or placebo, with a follow-up of just over 4 years (de Jager et al, 2010)

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On day 5, a maximum serum B12 concentration of 496 ± 34.4 pg/mL was recorded in the Sucrosomial ® B12 group compared to 304 ± 49.4 pg/mL in the conventional B-SUB B12 group (Figure 4 boxplots, bottom)

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