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Using the biosensor-based gating strategy, we sorted BMDMs infected with Mtb -roGFP2 at 24 h post-infection (p.i.), treated them with anti-TB drugs (INH, RIF, moxifloxacin (MOXI), and bedaquiline (BDQ) at 3X the in vitro minimum inhibitory concentration [MIC]) for 48 h, and confirmed that the E MSH -reduced fraction is uniformly more tolerant to multiple anti-TB drugs than the E MSH -oxidized fraction (Suppl

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Small samples, brief follow-up, and variable assays add further noise