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As a medication, it is used for its antioxidant properties to treat various conditions, including liver diseases, detoxification of heavy metals, and potentially for its skin-lightening effects

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on the other hand, oxidized phospholipids (such as oxidized PE) and lipid peroxides (LPO) released during ferroptosis can induce M2 macrophage polarization in the tumor microenvironment, promoting the expansion of regulatory T cells (Treg) by secreting immunosuppressive factors such as TGF-β and IL-10, and establishing a negative feedback mechanism for immune escape (43)