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The double-blind multicenter phase 3 trials STEP 1, 3, 4, 5 were conducted in adults (mean age 46.2–47.3 years), mostly females, with obesity or overweight with ≥1 weight-related complication (mean BMI 37.8–38.4 kg/m 2 ) and aimed to demonstrate the superiority of semaglutide 2.4 mg over placebo in BW lowering at 68 or 104 24 weeks as an adjunct to diet and physical activity 23

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Recent Developments in VEGFR Targeting in Pancreatic Cancer VEGFR-1 targeting has mainly employed kinase inhibitors that also target VEGFR-2 [47]