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It was first characterized in the early 1990s by Sikirić, Seiwerth, and colleagues in two foundational papers: a 1994 report in Life Sciences by Sikirić, Seiwerth, Grabarević, Petek, Rucman, and colleagues comparing BPC 157 to H2 antagonists, dopamine agonists, and other gut peptides across restraint-stress, cysteamine, and 96% ethanol rat ulcer models, in which BPC 157 regimens were consistently effective across all three lesion models, and a 1993 Journal of Physiology (Paris) paper by Sikirić, Petek, Rucman, Seiwerth, and colleagues identifying the 15-amino-acid fragment (from a larger ~40,000 molecular-weight gastric juice protein) as the portion essential for the compound's activity

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We hypothesized that host vitamin B12 modulates the activities of the skin microbiota and plays a role in acne pathogenesis