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Nonetheless, overexpression of both Ac/N-degron-bearing substrates, M-RGS2 ha and A-PLIN2 ha , and non-Ac/N-degron-bearing substrates, P-RGS2 ha and P-PLIN2 ha , considerably reduced lipid ROS levels, with non-Ac/N-degron substrates showing a more pronounced reduction (Fig