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Similarly, glutamine-derived α-ketoglutarate can also regulate the epigenome, as evidenced in IDH1/2 mutant gliomas, as it serves as a co-substrate for a class of dioxygenase enzymes

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ALA is a potent antioxidant, while ALCAR helps transport fatty acids into mitochondria to be used for energy, especially in high-demand tissues like the brain and heart