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Benefits (Research Focus) • IGF-1 receptor activation — studied for selective high-affinity agonism of the IGF-1 receptor • PI3K/Akt/mTOR signaling — investigated for downstream activation of cellular growth and protein synthesis pathways • Reduced IGFBP binding — explored for the Arg³ substitution that decreases IGF-binding protein affinity • Extended half-life — examined for ~20-30 hour bioactivity window compared to ~15 minutes for native IGF-1 • Skeletal muscle research — researched for satellite cell activation and protein synthesis endpoints in preclinical models What Researchers Look At • IGF-1R binding affinity and downstream phosphorylation cascades (IRS-1, Akt, S6K) • PI3K/Akt/mTOR pathway activation in muscle and metabolic cell models • IGFBP-3 binding affinity and free fraction pharmacokinetics • Skeletal muscle protein synthesis and satellite cell activation endpoints • Comparative bioactivity versus native IGF-1 and other IGF-1 analogs in cell-culture systems Quick Specs • Form: Lyophilized white powder • Net Peptide Content: 1 mg per vial • Quantity: 1 vial • Appearance: White to off-white lyophilizate • Reconstitution: Bacteriostatic or sterile water (added by the end researcher) • Purity: ≥99% by HPLC • Identity: MS-verified (per COA) • Storage: Protect from light Identity Basics • Compound: IGF-1 LR3 (Long [Arg³] Insulin-like Growth Factor-1) • Synonyms: Long R3 IGF-1