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In 2026, Trends in Pharmacological Sciences published a piece titled “Emerging opportunities for nicotinamide N-methyltransferase inhibitor clinical translation” (the 2026 Trends in Pharmacological Sciences review of emerging opportunities for NNMT inhibitor clinical translation)

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The full descriptions of these indicators can be found in the Medicare Claims Processing Manual, Chapter 23 at Additionally, we noted that a list of the codes we proposed to apply this adjustment to could be found under the Downloads section posted with the proposed rule at Finally, in the CY 2026 PFS proposed rule we explained that we understand that accruing efficiencies do not apply equally to all services, and that efficiencies gained over time may often apply more to services that take less time to perform