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In addition to having an impact on natural conception, elevated ROS levels can also have detrimental impacts on pregnancy outcomes following assisted reproductive techniques (ARTs) [7]

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The modulation of histamine further contributes to probiotics' anti-inflammatory actions where specific probiotic strains are able to produce histamine, which interacts with histamine-2 receptors on antigen-presenting cells, leading to decreased production of pro-inflammatory markers like TNF-α, IL-12, and monocyte chemotactic protein-1, and supporting anti-inflammatory pathways [23]