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PDF) Biosynthesis of prostaglandin 15dPGJ2 -glutathione and -cysteine conjugates in macrophages and mast cells via MGST3

78 While it may be tempting to conclude from these studies that NOX inhibition with celastrol or other drugs may represent an interesting therapeutic goal in COPD, it is important to recall that individuals with genetically defined NOX deficiencies are afflicted by life-threatening bacterial infections

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We first examine the principal discoveries from 1990 to 2000, followed by a review of the incremental information acquired from 2000 to 2026, thus summarizing the current state of the art as of 2026