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Xin-Ran Dong’s group found that puerarin promotes the proliferation and induces the differentiation of bone marrow mesenchymal stem cells (BMSCs) to chondrocytes by increasing the protein expression of collagen type II alpha 1 chain (COL2A 1), collagen type X alpha 1 chain (COL10A 1), MMP13, and SRY-related high-mobility-group box (SOX)-9, which has potential therapeutic effects in osteoarthritis (Dong et al., 2022)