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In mouse colitis models, engaging Siglec-F (such as with a Siglec-F antibody) leads to eosinophil apoptosis and has been shown to reduce colonic eosinophil numbers, although the impact on inflammation severity varied by model (some acute colitis models didn't improve, whereas chronic models or asthma models clearly benefited from eosinophil suppression) (205–208)

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Aerobic glycolysis plays a significant role in energy metabolism in chondrocytes, and in TMJ joints, both glucose and oxygen are critical for the survival of TMJ mesenchymal cells