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Not only were the L2HG levels reduced in A498-L2HGDH cells, but the volume of A498-L2HGDH tumors was reduced, as compared with controls [10]

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Nicotinamide nucleotide transhydrogenase NNT is an integral mitochondrial inner membrane protein in eukaryotes that catalyzes the transfer of hydride ions from NADH to NADP + and produces NADPH utilizing the proton motive force generated by the electron transport chain (ETC)