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The discrepancy is too large to be dismissed as a chance finding, suggest the researchers, but could be the result of publication bias—some studies might have been prioritized for publication because of the positive nature of their results whereas the unpublished datasets used in this study would not have been affected by any failure to publish null results

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A classic example is hepatocytes which secrete a high volume of albumin—by far the most abundant component of plasma—along with lipoproteins, clotting factors, and antiproteases