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Most cases (~90%) have no previous family history and hence are termed “sporadic ALS (sALS).” Specific environmental factors may increase the risk of developing ALS, including smoking, air pollution, agricultural and industrial pollutants, β-N-methyl amino-L-alanine (BMAA) toxicity, and physical activity

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It is reasonable to conclude that cells silenced for P65 exhibited even fewer live cells, displaying greater sensitivity to ferroptosis induced by RSL3 treatment, with a more pronounced trend (Fig