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Classical cancer cell death pattern. ROS, reactive oxygen species; GSH,... | Download Scientific Diagram
Other conditions known to influence expression of GCLC at the transcriptional level include treatments with antioxidants such as butylated hydroxyanisole [74,75], 5,10-dihydroindeno [1,2-b]indole and tert-butyl hydroquinone (TBH) [44,76,77], inducers of Phase II detoxifying enzymes such as β-naphthoflavone (β-NF) [78], formation of Michael reaction acceptors (containing an electrophilic electron-deficient center that is susceptible to nucleophilic attack) by treatment with diethyl maleate (DEM) to produce GSH conjugates [75], heat shock [79], zinc [80], melatonin [81], curcumin [82], and lipid peroxidation products such as 4-hydroxynonenal (4-HNE), 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ) [83–86], trivalent arsenite (As 3+ ) [87], and ajoene, a major compound in garlic extracts [88]
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