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10 However, it has been speculated that the T790M mutation lowers the affinity of the initial binding event of 7 before covalent linkage to Cys797 based on X-ray co-crystal analyses, which may have led to toxicity and lack of efficacy in the clinic

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[DOI] [PubMed] [Google Scholar] McQuillin A., Rizig M., Gurling H.M