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In addition, the assessment of the permeability of various molecules as well as the analyses of circulating cytokines secreted in the BBB-on-chip (via Luminex analysis of the medium perfused) provides a simple and physiologically accurate platform to study correlations between cytokine signaling and transporter gene/protein expression

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Disrupting the p53-FOXO4 interaction causes p53 to be excluded from the nucleus and directed to mitochondria for induction of apoptosis in senescent cells, ultimately eliminating senescent fibroblasts through triggering apoptosis (Baar et al., 2017)