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Pharmacotherapeutic Approaches to Treatment of Muscular Dystrophies

27 Decreased expression of xCT leads to an increase in the rate of sulphur transfer from homocysteine to cysteine (through the trans-sulphuration branch of the methionine cycle), supporting the pivotal role of xCT in cyst(e)ine transport and cysteine provision

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In about 30% of all autoimmune patients, autoantibodies against different ARSs (HisRS, ThrRS, AlaRS, IleRS, PheRS, GlyRS and AsnRS) have been found [110, 111]