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Nevertheless, in normal human fibroblasts, the enhanced expression of c-Myc and H-RasV12 induces oxidative stress while simultaneously reducing mitochondrial ETC activity, resulting in non-mitochondrial superoxide [43], indicating that the origin of oncogene-induced oxidative stress may depend on the cellular context

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Cabungcal J-H, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, et al

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