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Additionally, a Chinese study has shown excellent results with an oral formulation of ATO.34,91,92 Acute promyelocytic leukemia in older patients The management of APL is particularly challenging in elderly patients

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3.2 Mitochondrial metabolism and redox homeostasis While the glycolytic shift under hypoxia is a defining feature of tumor metabolism, alterations in mitochondrial function and redox homeostasis are equally critical to cancer cell adaptation (77)