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Symptoms of low levels of vitamin B12 include: A loss of appetite Weakness Tiredness Constipation Unexplained Weight Loss If you do not correct your deficiency in vitamin B12, your body will experience a number of more serious issues including: Depression Confusion which can lead to dementia Balance issues that can lead to falls and injuries Tingling in the hands and the feet Soreness in the mouth and in the tongue Short term memory loss Many people who are deficient in vitamin B12 tend to feel run down, depressed and low on energy