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Gene expression profiling showed upregulation of fatty acid oxidation genes including CPT1A and ACADM, indicating a metabolic shift from lipid storage toward lipid utilization

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Laboratory research involving 5-Amino-1MQ has focused on selective NNMT inhibition and its effect on diet-induced obesity in mouse models (Learn more), and the downstream metabolic consequences of changing nicotinamide methylation, alongside related work on other longevity and metabolic compounds such as [NAD+]