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1 Introduction Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD) ( Immunomodulatory therapies are established as effective treatments in ‘classical’ inflammatory neurological diseases, such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), or myasthenia gravis (MG) ( Various concepts have been tested as a causal treatment for PD, including vaccination against αSYN ( 2 Pathomechanisms of Neuroinflammation in PD Patients The pathophysiologic role of the immune system in PD is still enigmatic